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The 677T allele codes for an alanine to valine amino acid change and produces a thermolabile form of the enzyme that has 50–60% reduced enzyme activity at increased temperatures than the protein resulting from the allele with the more common 677C variant (Frosst et al., MTHFR is a key component of the folic acid metabolic cycle, and is therefore central to maintaining the balance of folic acid (folate, pteroylglutamic acid) to homocysteine in the body

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Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine